Nattokinase 6000FU

Nattokinase (200 mg, providing 6,000 FU of enzyme activity in Fibrinolytic Units) is a high-potency systemic fibrinolytic enzyme derived from the traditional Japanese fermented soybean dish known as natto. Discovered by Dr. Hiroyuki Sumi in 1987, nattokinase is one of the most potent naturally occurring fibrinolytic (clot-dissolving) enzymes ever identified — significantly more powerful than other dietary enzymes and with sustained activity lasting 8–12 hours in the bloodstream.
The Natto Discovery: Dr. Sumi, a researcher at the University of Chicago, was searching for natural clot-dissolving agents when he noticed that the enzyme produced by Bacillus subtilis natto (the bacteria that ferments natto) could dissolve artificial fibrin clots far more effectively than any known dietary enzyme. This discovery launched decades of research into nattokinase as a unique cardiovascular and circulatory support agent — fundamentally different from other proteolytic enzymes in its potency, durability, and specificity for fibrin.
Why 6,000 FU per day? FU (Fibrinolytic Units) is the standardized measure of nattokinase's specific activity — its ability to dissolve fibrin. Unlike simple weight (mg), FU measures actual clot-dissolving power. The clinical consensus is:
·         2,000 FU/day — maintenance dose for general cardiovascular health
·         4,000–6,000 FU/day — therapeutic dose for significant fibrin reduction, blood flow optimization, and cardiovascular support
·         6,000 FU (this product) — the well-established therapeutic dose used in most clinical studies, providing potent fibrinolysis without requiring multiple capsules
This formula targets five primary therapeutic pathways:
1.      Potent Fibrinolysis (Clot Dissolution) — Nattokinase is a direct-acting fibrinolytic enzyme that breaks down fibrin — the insoluble protein scaffolding of blood clots, arterial plaques, and scar tissue. It does this more effectively and more sustainably than any other dietary enzyme
2.      Endogenous Plasmin & tPA Activation — Unlike simple fibrinolytic enzymes, nattokinase also stimulates the body's own natural clot-dissolving system — increasing plasmin levels and tissue plasminogen activator (tPA) activity, while simultaneously reducing plasminogen activator inhibitor-1 (PAI-1). This creates a dual mechanism: direct fibrinolysis + sustained activation of the body's innate fibrinolytic system
3.      Blood Viscosity Reduction — Nattokinase reduces whole blood viscosity by breaking down fibrinogen (a key clotting protein) and preventing excessive red blood cell aggregation. Thinner blood flows more easily, reducing cardiac workload and improving microcirculation
4.      Blood Pressure Modulation — Nattokinase has a clinically documented blood pressure-lowering effect through its ability to inhibit angiotensin-converting enzyme (ACE) — the same mechanism as ACE inhibitor drugs (lisinopril, enalapril, ramipril). This is supported by multiple human clinical trials
5.      Antiplatelet Activity — Nattokinase inhibits platelet aggregation (clumping) without completely blocking platelet function, reducing the risk of inappropriate clot formation while preserving normal hemostatic function
Key Mechanisms of Action·         Direct Fibrin Degradation — Nattokinase directly cleaves cross-linked fibrin, the dense protein mesh that constitutes arterial thrombi (clots), deep vein thrombi, and the fibrous cap of atherosclerotic plaques. It is estimated to be 4–7 times more potent than plasmin (the body's natural fibrinolytic enzyme) in dissolving fibrin directly
·         Plasminogen-to-Plasmin Conversion — Nattokinase converts plasminogen into plasmin, the body's primary clot-dissolving enzyme. This amplifies the fibrinolytic effect far beyond what nattokinase alone could achieve, creating a sustained cascade of fibrin breakdown
·         tPA Upregulation & PAI-1 Inhibition — Nattokinase simultaneously:
o    Increases the production and activity of tissue plasminogen activator (tPA)
o    Decreases levels of plasminogen activator inhibitor-1 (PAI-1), the body's primary clot-promoting factor
o    This dual modulation shifts the entire coagulation/fibrinolysis balance toward healthy clot dissolution
·         Fibrinogen Reduction — Nattokinase reduces plasma fibrinogen levels by 10–15% over 4–8 weeks of use. Fibrinogen is both a clotting factor and a cardiovascular risk marker — elevated fibrinogen is an independent risk factor for heart disease and stroke
·         ACE Inhibition (Blood Pressure) — Nattokinase inhibits angiotensin-converting enzyme (ACE), reducing the production of angiotensin II (a potent vasoconstrictor) and decreasing blood pressure. Clinical studies show reductions of 5–15 mmHg systolic and 3–8 mmHg diastolic in hypertensive individuals
·         Blood Viscosity Normalization — By reducing fibrinogen, breaking down existing fibrin, and preventing red blood cell aggregation, nattokinase reduces whole blood viscosity. Thinner blood:
o    Reduces cardiac workload
o    Improves microcirculation (capillary blood flow)
o    Enhances oxygen and nutrient delivery to tissues
o    Reduces the risk of thrombotic events (heart attack, stroke, DVT)
·         Antioxidant Activity (Mild) — Natto and nattokinase contain isoflavones and other antioxidants with mild free-radical scavenging activity, supporting vascular health
·         Anti-Inflammatory Effects — By dissolving fibrin deposits that trigger chronic inflammation, and through direct modulation of inflammatory mediators, nattokinase has a mild systemic anti-inflammatory effect
Key Benefits·         Cardiovascular Protection — Nattokinase is one of the most comprehensively studied natural compounds for cardiovascular health. Its combination of fibrinolysis, blood pressure reduction, blood viscosity improvement, and antiplatelet activity provides multi-target cardiovascular support
·         Healthy Blood Pressure — Clinically documented blood pressure reduction in multiple human trials — particularly beneficial for those with stage 1 hypertension (130–140/80–90 mmHg)
·         Improved Circulation — Reduced blood viscosity and improved microcirculation produce noticeable benefits: warmer extremities, reduced cold hands and feet, improved exercise recovery, and better cognitive blood flow
·         Stroke & Heart Attack Prevention — By dissolving existing fibrin, preventing clot formation, and improving blood flow parameters, nattokinase reduces risk factors for thrombotic events
·         Deep Vein Thrombosis (DVT) Prevention — Particularly valuable for those at risk of DVT: long-haul air travel, prolonged immobilization, post-surgical recovery, or genetic clotting tendencies
·         Peripheral Artery Disease (PAD) Support — Improved circulation to the extremities reduces claudication (leg pain on walking), cold feet, and non-healing ulcers
·         Varicose Vein & Hemorrhoid Support — Improved venous circulation and reduced fibrin deposition around weakened veins
·         Reduced "Thick Blood" Symptoms — Many individuals with elevated fibrinogen levels report that nattokinase relieves symptoms of "thick blood": chronic fatigue, brain fog, headaches, heavy feeling in the legs
·         Sinus & Respiratory Health — Through its fibrinolytic and mucolytic effects, nattokinase can improve sinus drainage and reduce chronic sinus congestion
·         Post-COVID & Long COVID Support — Emerging clinical interest in nattokinase for dissolving the micro-clots and fibrin deposits associated with post-COVID syndrome and Long COVID
·         Endometriosis & Uterine Fibroid Support — May help break down the fibrin and fibrous tissue associated with endometriosis lesions and uterine fibroids
·         Eye Health — Improved microcirculation to the retina supports eye health and may help with conditions involving retinal microvascular insufficiency
·         Post-Surgical Recovery — Reduces risk of post-operative DVT and adhesions, and improves recovery of normal circulation
Who Is It For?·         Individuals with cardiovascular risk factors — including:
o    Family history of heart disease, heart attack, or stroke
o    High blood pressure (hypertension)
o    High cholesterol or triglycerides
o    Elevated fibrinogen levels
o    Diabetes or pre-diabetes
o    Metabolic syndrome
·         People with elevated blood pressure — particularly stage 1 hypertension (130–139/80–89 mmHg) seeking a natural approach to blood pressure management. Nattokinase has the most clinical evidence for blood pressure reduction among all natural compounds
·         Those concerned about stroke or heart attack prevention — as a natural, side-effect-free alternative or adjunct to pharmaceutical blood thinners (with appropriate medical supervision)
·         Air travelers — for DVT prevention during long-haul flights (4+ hours). Take one dose before the flight and one during if the flight exceeds 8 hours
·         Post-surgical patients — for DVT prevention and improved recovery of circulation. Must be discussed with the surgeon and discontinued before surgery (see precautions)
·         Individuals with "thick blood" or elevated fibrinogen — many patients discover this through lab work or symptoms like fatigue, brain fog, and heavy legs
·         Those with varicose veins, hemorrhoids, or chronic venous insufficiency — improved venous return and reduced fibrin deposition provide symptomatic relief
·         People with peripheral artery disease (PAD) — improved walking distance and reduced claudication pain
·         Older adults — natural fibrinolytic activity declines with age, while fibrinogen levels rise. Nattokinase helps restore the youthful balance of the coagulation system
·         Biohackers and longevity enthusiasts — nattokinase is widely used for cardiovascular optimization, blood flow enhancement, and reducing age-related clotting risk
·         Athletes — improved microcirculation enhances oxygen delivery to working muscles, reduces recovery time, and may improve endurance
·         Individuals with chronic sinusitis — nattokinase's fibrinolytic effects improve mucus clearance and sinus drainage
·         Those with endometriosis or uterine fibroids — may help break down the fibrous tissue characteristic of these conditions
·         Post-COVID / Long COVID patients — emerging evidence supports nattokinase for dissolving the micro-clots and fibrin deposits contributing to persistent post-COVID symptoms
·         Individuals with cold hands and feet — improved microcirculation often produces noticeable warming of the extremities
·         People with tinnitus (ringing in the ears) of vascular origin — improved inner ear microcirculation may reduce symptoms
·         Healthy individuals seeking cardiovascular maintenance — as a daily preventive for maintaining healthy blood flow, coagulation balance, and blood pressure
Instructions for UseRecommended Dosage
Timing
Course Duration
1 capsule (200 mg / 6,000 FU) per day
Take on an empty stomach — at least 30 minutes before meals or 2 hours after meals
Suitable for long-term daily use
Usage Notes:
·         CRITICAL: Take on an empty stomach — Nattokinase is a proteolytic enzyme that digests protein. If taken with food, it will digest food proteins rather than being absorbed into the bloodstream to exert its systemic fibrinolytic effects. Take 30+ minutes before a meal or 2+ hours after a meal with a full glass of water
·         Timing recommendations:
o    Morning (empty stomach) — First thing upon waking, then wait 30 minutes before breakfast. This establishes a consistent routine
o    Bedtime — 2 hours after the last meal. Fibrin production and blood viscosity naturally increase during sleep, making night-time fibrinolysis particularly valuable
o    Split dosing (advanced) — For those seeking enhanced effects: 3,000 FU (½ capsule) in the morning + 3,000 FU (½ capsule) at bedtime. This maintains more consistent blood levels
·         Absorption window — Nattokinase absorption begins within 30–60 minutes of oral ingestion, with peak fibrinolytic activity in the blood at 4–6 hours after dosing. Fibrinolytic effects persist for 8–12 hours
·         Consistency is essential — Unlike acute medications, nattokinase's benefits are cumulative and sustained. Optimal cardiovascular protection develops over 4–12 weeks of daily use and is maintained by continued use
·         Duration — Suitable for indefinite daily use. Nattokinase does not require cycling and can be taken year-round for continuous cardiovascular and circulatory support. Most users take it daily for months to years
·         Hydration — Drink adequate water (1.5–2 liters/day) to maintain healthy blood volume and viscosity. Dehydration increases blood viscosity and counteracts nattokinase's benefits
·         Stacking synergy — Nattokinase pairs exceptionally well with:
o    Serrapeptase — complementary fibrinolytic for enhanced clot and plaque dissolution. Both enzymes work through different fibrinolytic mechanisms, creating a synergistic effect
o    Omega-3 fatty acids (EPA/DHA) — anti-inflammatory and antithrombotic synergy for comprehensive cardiovascular support
o    CoQ10 — cardiovascular energy support for the heart muscle
o    Magnesium (glycinate or taurate) — blood pressure regulation and vascular relaxation
o    Curcumin (with piperine) — anti-inflammatory synergy for vascular health
o    Garlic extract (allicin) — complementary blood pressure and cholesterol support
o    Hawthorn berry — traditional cardiovascular tonic for heart function and circulation
·         Dietary considerations — Nattokinase is naturally derived from soy (natto). While the enzyme itself is purified, individuals with severe soy allergies should check with their manufacturer about soy protein residues
·         If you forget a dose — skip the missed dose and resume your normal schedule the next day. Do not double-dose
·         Storage — Store in a cool, dry place below 25°C (77°F). Avoid heat and humidity, which can degrade enzyme activity
Precautions·         Consult a healthcare professional before use if you:
o    Are taking anticoagulant or antiplatelet medications — INCLUDING: warfarin (Coumadin), acenocoumarol (Sintrom), apixaban (Eliquis), rivaroxaban (Xarelto), dabigatran (Pradaxa), edoxaban (Lixiana), clopidogrel (Plavix), ticagrelor (Brilinta), prasugrel (Effient), dipyridamole, cilostazol, heparin, enoxaparin (Lovenox), aspirin (including low-dose "baby aspirin" 75–100 mg), NSAIDs (ibuprofen, naproxen, diclofenac, ketorolac). Nattokinase has potent fibrinolytic and antiplatelet activity — combining it with blood thinners may significantly increase bleeding risk. This combination should only be used under strict medical supervision with regular monitoring
o    Have a bleeding disorder (hemophilia, von Willebrand disease, thrombocytopenia, or any clotting factor deficiency)
o    Are scheduled for surgery — CRITICAL: Discontinue nattokinase at least 2 weeks (14 days) before any surgical procedure, dental extraction, or invasive medical procedure. Nattokinase's fibrinolytic effect persists for 8–12 hours per dose, and its cumulative effect on coagulation parameters takes approximately 14 days to fully reverse. Failure to discontinue before surgery may significantly increase bleeding risk
o    Have a history of peptic ulcer, gastritis, or gastrointestinal bleeding
o    Have had a hemorrhagic stroke (bleeding in the brain)
o    Have active internal bleeding or are at risk of bleeding (recent trauma, recent surgery, known aneurysm, esophageal varices)
o    Have severe liver disease (cirrhosis, hepatitis) — the liver produces clotting factors that may already be compromised; nattokinase may further unbalance coagulation
o    Have severe kidney disease
o    Have uncontrolled severe hypertension (>160/100 mmHg) — there is a small risk of hemorrhagic conversion if blood pressure is not controlled while taking a fibrinolytic agent
o    Have a known allergy to soy or soy products — nattokinase is derived from soy fermentation; while highly purified, trace soy residues may be present
o    Are pregnant, breastfeeding, or planning to become pregnant — nattokinase is not recommended during pregnancy due to its fibrinolytic effects on the placental circulation. The placenta relies on a delicate balance of coagulation and fibrinolysis
o    Have a recent history of significant bleeding without known cause
o    Have chronic liver or kidney disease — discuss with your doctor before use
·         Possible side effects are generally rare and mild:
o    Mild gastrointestinal upset — very rare; nausea, loose stools, or mild abdominal discomfort can occur in the first few days. Usually resolves spontaneously. Taking on an empty stomach reduces this risk in most users
o    Increased bleeding tendency — prolonged bleeding time, easy bruising, nosebleeds, bleeding gums, heavier menstrual bleeding. If you notice any of these, discontinue and consult your healthcare provider immediately
o    Skin reactions — rare; mild rash or hives in sensitive individuals
o    Headache — uncommon; usually mild and transient
o    Dizziness — rare; could be related to blood pressure changes
o    No known liver or kidney toxicity — nattokinase has an excellent safety profile in long-term use
·         When to discontinue use and seek medical attention:
o    Unexplained or excessive bruising
o    Bloody or black, tarry stools (sign of gastrointestinal bleeding)
o    Blood in urine
o    Vomiting blood or material resembling coffee grounds
o    Unusually heavy or prolonged menstrual bleeding
o    Prolonged bleeding from minor cuts or injuries
o    Frequent or prolonged nosebleeds
o    Sudden severe headache (possible sign of hemorrhagic stroke)
o    Sudden vision changes or loss of vision
o    Coughing up blood
o    Signs of allergic reaction (rash, hives, swelling of face/throat, difficulty breathing)
o    Any unusual bleeding without a clear cause
·         Before routine medical tests or dental work: Inform your healthcare providers that you are taking nattokinase. Some procedures and tests (such as INR/PT/PTT blood tests, biopsies, injections, and dental cleanings with heavy scaling) may be affected
·         Do not exceed recommended dose — 6,000 FU (200 mg) daily is the clinically established therapeutic dose. Higher doses increase bleeding risk without proven additional benefit
·         Keep out of reach of children
This product is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease